Selective Bibliography of Dr. John Brognard
Laboratory of Cell and Developmental Signaling, NCI

Wednesday, May 24, 2023

1. Torres-Ayuso P, An E, Nyswaner KM, Bensen RC, Ritt DA, Specht SI, Das S, Andresson T, Cachau RE, Liang RJ, Ries AL, Robinson CM, Difilippantonio S, Gouker B, Bassel L, Karim BO, Miller CJ, Turk BE, Morrison DK, Brognard J
   TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin
   Cancer Discovery 11 (6):1411-1423 Jun 2021
2. Hoang VT, Nyswaner K, Torres-Ayuso P, Brognard J
   The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells
   The Journal of Biological Chemistry 295 (25):8470-8479 Jun 19 2020
3. Torres-Ayuso P, Sahoo S, Ashton G, An E, Simms N, Galvin M, Leong HS, Frese KK, Simpson K, Cook N, Hughes A, Miller CJ, Marais R, Dive C, Krebs MG, Brognard J
   Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin
   NPJ Genomic Medicine 3 15 Jun 20 2018
4. Hudson AM, Stephenson NL, Li C, Trotter E, Fletcher AJ, Katona G, Bieniasz-Krzywiec P, Howell M, Wirth C, Furney S, Miller CJ, Brognard J
   Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases
   Science Signaling 11 (526):Apr 17 2018
5. Edwards ZC, Trotter EW, Torres-Ayuso P, Chapman P, Wood HM, Nyswaner K, Brognard J
   Survival of Head and Neck Cancer Cells Relies upon LZK Kinase-Mediated Stabilization of Mutant p53
   Cancer Research 77 (18):4961-4972 Sep 15 2017
6. Testoni E, Stephenson NL, Torres-Ayuso P, Marusiak AA, Trotter EW, Hudson A, Hodgkinson CL, Morrow CJ, Dive C, Brognard J
   Somatically mutated ABL1 is an actionable and essential NSCLC survival gene
   EMBO Molecular Medicine 8 (2):105-16 Feb 1 2016
7. Marusiak AA, Stephenson NL, Baik H, Trotter EW, Li Y, Blyth K, Mason S, Chapman P, Puto LA, Read JA, Brassington C, Pollard HK, Phillips C, Green I, Overman R, Collier M, Testoni E, Miller CJ, Hunter T, Sansom OJ, Brognard J
   Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis
   Cancer Research 76 (3):724-35 Feb 1 2016
8. Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC
   Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor
   Cell 160 (3):489-502 Jan 29 2015
9. Hudson AM, Yates T, Li Y, Trotter EW, Fawdar S, Chapman P, Lorigan P, Biankin A, Miller CJ, Brognard J
   Discrepancies in cancer genomic sequencing highlight opportunities for driver mutation discovery
   Cancer Research 74 (22):6390-6396 Nov 15 2014
10. Marusiak AA, Edwards ZC, Hugo W, Trotter EW, Girotti MR, Stephenson NL, Kong X, Gartside MG, Fawdar S, Hudson A, Breitwieser W, Hayward NK, Marais R, Lo RS, Brognard J
    Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
    Nature Communications 5 3901 May 22 2014