Selective Bibliography of Dr. Dhirendra Simanshu
Structural Biology, RAS Initiative, FNL

“Structural and Mechanistic Insights into the RAS Biology“
Monday, October 24, 2022

1.  Simanshu DK, Morrison DK
A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation
Cancer Discovery 12 (4):899-912 Apr 1 2022

2.  Castel P, Dharmaiah S, Sale MJ, Messing S, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D, Simanshu DK, McCormick F
RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity
Proceedings of the National Academy of Sciences of the United States of America 118 (33):Aug 17 2021

3.  Tran TH, Chan AH, Young LC, Bindu L, Neale C, Messing S, Dharmaiah S, Taylor T, Denson JP, Esposito D, Nissley DV, Stephen AG, McCormick F, Simanshu DK
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
Nature Communications 12 (1):1176 Feb 19 2021

4.  Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK
Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR
Cell Reports 32 (3):107909 Jul 21 2020

5. Nelson AC, Turbyville TJ, Dharmaiah S, Rigby M, Yang R, Wang TY, Columbus J, Stephens R, Taylor T, Sciacca D, Onsongo G, Sarver A, Subramanian S, Nissley DV, Simanshu DK, Lou E 
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling
Journal of Biological Chemistry 295 (28):9335-9348 Jul 10 2020

6.  Rabara D, Tran TH, Dharmaiah S, Stephens RM, McCormick F, Simanshu DK, Holderfield M
KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis
Proceedings of the National Academy of Sciences of the United States of America 116 (44):22122-22131 Oct 29 2019

7.  Dharmaiah S, Tran TH, Messing S, Agamasu C, Gillette WK, Yan W, Waybright T, Alexander P, Esposito D, Nissley DV, McCormick F, Stephen AG, Simanshu DK
Structures of N-terminally processed KRAS provide insight into the role of N-acetylation
Scientific Reports 9 (1):10512 Jul 19 2019

8.  Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F
RIT1 oncoproteins escape LZTR1-mediated proteolysis
Science 363 (6432):1226-1230 Mar 15 2019

9.  Simanshu DK, Nissley DV, McCormick F
RAS Proteins and Their Regulators in Human Disease
Cell 170 (1):17-33 Jun 29 2017

10.  Dharmaiah S, Bindu L, Tran TH, Gillette WK, Frank PH, Ghirlando R, Nissley DV, Esposito D, McCormick F, Stephen AG, Simanshu DK
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ
Proceedings of the National Academy of Sciences of the United States of America 113 (44):E6766-e6775 Nov 1 2016