Selective Bibliography of Dr. Chengkai Dai
Mouse Cancer Genetics Program, NCI

"A Powerful Enabler of Oncogenesis: Implications of HSF1 in Proteomic Instability and Non-Oncogene Addiction of Cancer"

Wednesday, June 14, 2023

1.  Xu M, Lin L, Chuang, K-H, Ram B, Dai S, Su K-H, Tang Z, Dai C
Heat Shock Factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat-shock response
Cell Reports (In press) 2023 

2.  Choudhury A, Ratna A, Lim A, Sebastian RM, Moore CL, Filliol AA, Bledsoe J, Dai C, Schwabe RF, Shoulders MD, Mandrekar P
Loss of heat shock factor 1 promotes hepatic stellate cell activation and drives liver fibrosis
Hepatology Communications 6 (10):2781-2797 Oct 2022

3.  Tang Z, Su KH, Xu M, Dai C
HSF1 physically neutralizes amyloid oligomers to empower overgrowth and bestow neuroprotection
Science Advances 6 (46):Nov 2020

4.  Su KH, Dai S, Tang Z, Xu M, Dai C
Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase
Molecular Cell 76 (4):546-561.e8 Nov 21 2019

5.  Su KH, Cao J, Tang Z, Dai S, He Y, Sampson SB, Benjamin IJ, Dai C
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth
Nature Cell Biology 18 (5):527-39 May 2016

6.  Dai C, Sampson SB
HSF1: Guardian of Proteostasis in Cancer
Trends in Cell Biology 26 (1):17-28 Jan 2016

7.  Tang Z, Dai S, He Y, Doty RA, Shultz LD, Sampson SB, Dai C
MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1
Cell 160 (4):729-744 Feb 12 2015

8.  Dai S, Tang Z, Cao J, Zhou W, Li H, Sampson S, Dai C
Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK
The Embo Journal 34 (3):275-93 Feb 3 2015

9.  Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, Bronson RT, Whitesell L, Lindquist S
Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis
The Journal of Clinical Investigation 122 (10):3742-54 Oct 2012

10.  Dai C, Whitesell L, Rogers AB, Lindquist S
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
Cell 130 (6):1005-18 Sep 21 2007