Selective Bibliography of Dr. Matthew Holderfield
RAS Project: Drug Discovery Assays and Screens, Leidos

"Targeting KRAS: Developing Treatments for an Undruggable Protein"
Wednesday, October 5, 2016

1.  Wang MT, Holderfield M, Galeas J, Delrosario R, To MD, Balmain A, McCormick F
K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling
Cell 163 (5):1237-51 Nov 19 2015

2.  Gillette WK, Esposito D, Abreu Blanco M, Alexander P, Bindu L, Bittner C, Chertov O, Frank PH, Grose C, Jones JE, Meng Z, Perkins S, Van Q, Ghirlando R, Fivash M, Nissley DV, McCormick F, Holderfield M, Stephen AG
Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions
Scientific Reports 5:15916 2015

3.  Rubio CA, Weisburd B, Holderfield M, Arias C, Fang E, DeRisi JL, Fanidi A
Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation
Genome Biology 15 (10):476 2014

4.  Holderfield M, Nagel TE, Stuart DD
Mechanism and consequences of RAF kinase activation by small-molecule inhibitors
British Journal of Cancer 111 (4):640-5 Aug 12 2014

5.  Holderfield M, Deuker MM, McCormick F, McMahon M
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond
Nature Reviews. Cancer 14 (7):455-67 Jul 2014

6.  Popson SA, Ziegler ME, Chen X, Holderfield MT, Shaaban CI, Fong AH, Welch-Reardon KM, Papkoff J, Hughes CC
Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis
Arteriosclerosis, Thrombosis, and Vascular Biology 34 (5):1011-9 May 2014

7.  Holderfield M, Lorenzana E, Weisburd B, Lomovasky L, Boussemart L, Lacroix L, Tomasic G, Favre M, Vagner S, Robert C, Ghoddusi M, Daniel D, Pryer N, McCormick F, Stuart D
Vemurafenib cooperates with HPV to promote initiation of cutaneous tumors
Cancer Research 74 (8):2238-45 Apr 15 2014

8.  Holderfield M, Merritt H, Chan J, Wallroth M, Tandeske L, Zhai H, Tellew J, Hardy S, Hekmat-Nejad M, Stuart DD, McCormick F, Nagel TE
RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation
Cancer Cell 23 (5):594-602 May 13 2013

9.  Sainson RC, Johnston DA, Chu HC, Holderfield MT, Nakatsu MN, Crampton SP, Davis J, Conn E, Hughes CC
TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype
Blood 111 (10):4997-5007 May 15 2008

10.  Holderfield MT, Hughes CC
Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis
Circulation Research 102 (6):637-52 Mar 28 2008