Selective Bibliography of  Dr. Stephen Hughes
HIV Dynamics and Replication Program, NCI

"Insertional Activation of STAT3 and LCK by HIV-1 Proviruses in T"
Wednesday, March 24, 2021

1.  Maldarelli F, Wu X, Su L, Simonetti FR, Shao W, Hill S, Spindler J, Ferris AL, Mellors JW, Kearney MF, Coffin JM, Hughes SH
HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
Science 345 (6193):179-83 Jul 11 2014
    
2.  Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A, Hughes SH
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration
Proceedings of the National Academy of Sciences of the United States of America 107 (7):3135-40 Feb 16 2010

3.  Boyer PL, Sarafianos SG, Arnold E, Hughes SH
Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
Journal of Virology 75 (10):4832-42 May 2001

4.  Federspiel MJ, Bates P, Young JA, Varmus HE, Hughes SH
A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors
Proceedings of the National Academy of Sciences of the United States of America 91 (23):11241-5 Nov 8 1994

5.  Jacobo-Molina A, Ding J, Nanni RG, Clark AD, Jr., Lu X, Tantillo C, Williams RL, Kamer G, Ferris AL, Clark P, et al.
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA
Proceedings of the National Academy of Sciences of the United States of America 90 (13):6320-4 Jul 1 1993

6.  Smith SJ, Zhao XZ, Passos DO, Lyumkis D, Burke TR, Jr., Hughes SH
Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs
Viruses 13 (2):Jan 29 2021

7.  Halvas EK, Joseph KW, Brandt LD, Guo S, Sobolewski MD, Jacobs JL, Tumiotto C, Bui JK, Cyktor JC, Keele BF, Morse GD, Bale MJ, Shao W, Kearney MF, Coffin JM, Rausch JW, Wu X, Hughes SH, Mellors JW
HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus
The Journal of Clinical Investigation 130 (11):5847-5857 Nov 2 2020

8.  Passos DO, Li M, Józwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke TR, Jr., Craigie R, Lyumkis D
Structural basis for strand-transfer inhibitor binding to HIV intasomes
Science 367 (6479):810-814 Feb 14 2020

9.  Ferris AL, Wells DW, Guo S, Del Prete GQ, Swanstrom AE, Coffin JM, Wu X, Lifson JD, Hughes SH
Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans
PLoS Pathogens 15 (7):e1007869 Jul 2019

10.  Coffin JM, Wells DW, Zerbato JM, Kuruc JD, Guo S, Luke BT, Eron JJ, Bale M, Spindler J, Simonetti FR, Hill S, Kearney MF, Maldarelli F, Wu X, Mellors JW, Hughes SH
Clones of infected cells arise early in HIV-infected individuals
JCI Insight 4 (12):Jun 20 2019