Selective Bibliography of Dr. Andy Stephen  
RAS Initiative Biochemistry & Biophysics Research, NCI

"Activation of RAF1 kinase by RAS proteins at the plasma membrane"
Wednesday, October 11, 2023

1.  Spencer-Smith R, Terrell EM, Insinna C, Agamasu C, Wagner ME, Ritt DA, Stauffer J, Stephen AG, Morrison DK
RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation
Molecular Cell 82 (22):4262-4276.e5 Nov 17 2022

2.  Ingólfsson HI, Neale C, Carpenter TS, Shrestha R, López CA, Tran TH, Oppelstrup T, Bhatia H, Stanton LG, Zhang X, Sundram S, Di Natale F, Agarwal A, Dharuman G, Kokkila Schumacher SIL, Turbyville T, Gulten G, Van QN, Goswami D, Jean-Francois F, Agamasu C, Chen D, Hettige JJ, Travers T, Sarkar S, Surh MP, Yang Y, Moody A, Liu S, Van Essen BC, Voter AF, Ramanathan A, Hengartner NW, Simanshu DK, Stephen AG, Bremer PT, Gnanakaran S, Glosli JN, Lightstone FC, McCormick F, Nissley DV, Streitz FH
Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins
Proceedings of the National Academy of Sciences of the United States of America 119 (1):Jan 4 2022

3.  Tran TH, Chan AH, Young LC, Bindu L, Neale C, Messing S, Dharmaiah S, Taylor T, Denson JP, Esposito D, Nissley DV, Stephen AG, McCormick F, Simanshu DK
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
Nature Communications 12 (1):1176 Feb 19 2021

4.  Heinrich F, Van QN, Jean-Francois F, Stephen AG, Lösche M
Membrane-bound KRAS approximates an entropic ensemble of configurations
Biophysical Journal 120 (18):4055-4066 Sep 21 2021

5.  Van QN, López CA, Tonelli M, Taylor T, Niu B, Stanley CB, Bhowmik D, Tran TH, Frank PH, Messing S, Alexander P, Scott D, Ye X, Drew M, Chertov O, Lösche M, Ramanathan A, Gross ML, Hengartner NW, Westler WM, Markley JL, Simanshu DK, Nissley DV, Gillette WK, Esposito D, McCormick F, Gnanakaran S, Heinrich F, Stephen AG
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane
Proceedings of the National Academy of Sciences of the United States of America 117 (39):24258-24268 Sep 29 2020

6.  Travers T, López CA, Agamasu C, Hettige JJ, Messing S, García AE, Stephen AG, Gnanakaran S
Anionic Lipids Impact RAS-Binding Site Accessibility and Membrane Binding Affinity of CRAF RBD-CRD
Biophysical Journal 119 (3):525-538 Aug 4 2020

7.  Travers T, López CA, Van QN, Neale C, Tonelli M, Stephen AG, Gnanakaran S
Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain
Scientific Reports 8 (1):8461 May 31 2018

8.  Gillette WK, Esposito D, Abreu Blanco M, Alexander P, Bindu L, Bittner C, Chertov O, Frank PH, Grose C, Jones JE, Meng Z, Perkins S, Van Q, Ghirlando R, Fivash M, Nissley DV, McCormick F, Holderfield M, Stephen AG
Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions
Scientific Reports 5 15916 Nov 2 2015

9.  Stephen AG, Esposito D, Bagni RK, McCormick F
Dragging ras back in the ring
Cancer Cell 25 (3):272-81 Mar 17 2014